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Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc

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Excessive production of reactive oxygen species (ROS) activates redox-sensitive signalling pathways such as NF-B, leading to sustained release of pro-inflammatory cytokines including TNF-, IL-6, and IL-1, which impair fibroblast function, collagen synthesis, keratinocyte migration, and neovascularisation

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PubMed Fras JP, et al